Research

Led by Hossein Estiri, the Clinical Augmented Intelligence Group builds clinical AI that understands time, place, and the limits of its own data. Our research spans temporal phenotyping, agentic clinical AI, diagnostic data fidelity, and environmental health informatics.

Signal strength
Topic
Health area
The Right Trial, for the Right Patients
Event Nov 2026

The Right Trial, for the Right Patients

At the RECOVER-TLC workshop, we argued that health records and AI can test a treatment idea in weeks, before a trial enrolls its first patient

Long COVIDPhenotypingPrecision medicineAugmented intelligence
COVID-19Population health
The Phylophenome: A Temporal Map of Human Disease
Pattern Oct 2026

The Phylophenome: A Temporal Map of Human Disease

ClaiD maps which conditions tend to follow which, and over what interval, across 300,000 patient records

PhylophenomeTemporalityPhenotyping
CardiovascularKidneyCognitive health
Absent From the Code
Finding Oct 2026

Absent From the Code

Diagnostic codes capture fewer than half of Long COVID cases across 58 US hospitals

Long COVIDPhenotypingSignal fidelity
COVID-19Population health
A National Neural Network for Health Care
Finding Jan 2026

A National Neural Network for Health Care

Coordinating federal broadband funding with clinical AI could extend care to the regions with the fewest physicians

Augmented intelligenceFederated inference
Health systemsPopulation health
Building a Digital Clinical Team
Finding Jan 2026

Building a Digital Clinical Team

Five AI Agents That Critique Each Other — And Outperform Human Prompt Engineering

Agentic AIDementia
Cognitive healthAging
The Average Patient Fallacy
Signal Oct 2025

The Average Patient Fallacy

Why Medical AI Fails the Patients Who Need It Most—And How to Fix It

PhenomenologyPrecision medicine
Precision medicine
The AI Black Box
Signal Jul 2025

The AI Black Box

A Looming Threat to Medical Transparency

AI safetyInterpretability
Health systems
Thinkin' AI with MLHO
Finding Jun 2022

Thinkin' AI with MLHO

A data-centric approach AI/ML system that learns over time

Augmented intelligenceTemporality
COVID-19
CLAI
Pattern Jun 2022

CLAI

a lab for CLinical Augmented Intelligence

PhenomenologyAugmented intelligence
An ICD story
Pattern May 2022

An ICD story

story of how we find true moments of individual records from the EHR with tSPM

TemporalitySignal fidelity
Population health
Research Impact
In the press May 2022

Research Impact

Research with national and international impact

COVID-19
Evaluating Bias in Medical AI
Pattern May 2022

Evaluating Bias in Medical AI

An objective framework for evaluating unrecognized bias in medical AI models

AI safetyFairness
COVID-19Health equity