The Right Trial, for the Right Patients
At the RECOVER-TLC workshop, we argued that health records and AI can test a treatment idea in weeks, before a trial enrolls its first patient
COVID-19
Population healthClinical Augmented Intelligence Group · Massachusetts General Hospital · Harvard Medical School · Broad Institute of MIT and Harvard
We build clinical AI that understands time, place, and the limits of its own data.
Research on agentic clinical AI, temporal phenotyping, diagnostic data fidelity, and environmental health, from electronic health records spanning dozens of hospitals.
Each piece carries a signal strength: Signalan early idea Patterna result taking shape Findingpeer-reviewed
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Research
Essays, tools, and perspectives, filed by topic
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Agentic AI
Phylophenome
Exposomics
Temporality
Phenomenology
Signal fidelity
Long COVID
Augmented intelligence
COVID-19Population health
Absent From the Code
Diagnostic codes capture fewer than half of Long COVID cases across 58 US hospitals
COVID-19Population health
Pythia: Open-Source Prompt Optimization for Clinical AI
Pythia, the multi-agent prompt optimization engine behind our clinical symptom detection work, is now open source
Clinical symptoms
Self-Optimizing Prompts for Clinical Symptom Detection
A multi-agent system writes, tests, and revises its own prompts to detect 72 signs and symptoms in clinical notes
Clinical symptoms
The Phylophenome: A Temporal Map of Human Disease
ClaiD maps which conditions tend to follow which, and over what interval, across 300,000 patient records
Cardiovascular
Kidney
Cognitive health
The Opportunity Cost of Market Narratives in Health Care AI
A NAM Perspective on what health systems give up when AI spending outruns the evidence
Health systems
Optimization Instability in Autonomous Agents
When AI Systems That Improve Themselves Make Themselves Worse
Clinical symptoms
A National Neural Network for Health Care
Coordinating federal broadband funding with clinical AI could extend care to the regions with the fewest physicians
Health systemsPopulation health
Building a Digital Clinical Team
Five AI Agents That Critique Each Other — And Outperform Human Prompt Engineering
Cognitive health
AgingNews
Grants, papers, talks, and press- Jul 2026 Keynote at IWBBIO 2026 Talk
- Jun 2026 NAM Perspectives commentary on market narratives in health care AI Publication
- May 2026 Long COVID surveillance gaps press coverage Publication
- May 2026 Long COVID surveillance gaps across 58 US hospitals published in JAMA Network Open Publication
- Jan 2026 Milbank Quarterly opinion on AI and broadband as health infrastructure Publication
- Jan 2026 Agentic workflow for cognitive concerns press coverage Publication
- Sep 2025 Dr. Estiri joins HHS Long COVID roundtables Service
- Dec 2024 P2RC press coverage Publication
